Conclusion Arthroscopic release with radiofrequency vaporization for knee joint stiffness is characterized by less bleeding, minor trauma and reliable release and can be applicable especially for the eases with only adhesion at suprapatellar bursa, lateral groove or joint compartment. 结论关节镜下射频汽化消融松解膝关节粘连出血少,创伤小,松解效果可靠,可避免以往方法的不利因素,对于髌上囊、侧沟或关节间隙粘连的患者尤为适用。
Review on DNA minor groove binders as antitumor drugs 抗肿瘤药物DNA小沟区结合剂的研究进展
Synthetic polyamides can bind to specific nucleotide sequences in the minor groove of double-helical DNA with high affinity and specificity and influence gene expression. PIP are chemical compounds that are completely resistant to nucleases and do not require particular delivery systems. 研究表明PIP能在双螺旋DNA小沟处与特异性核酸序列紧密结合,影响基因表达;同时,PIP可抵抗核酸酶的降解,不需要特殊的转运系统。
Simulation results were consistent with experimental results, showing that EGCG is connected in DNA G-C rich area with minor groove mode. 4. 模拟的结果与实验一致,且显示出EGCG以小沟槽模式结合在DNA的G-C富裕区。
Our simulation results indicated that a DNA molecule bound by a reversible amidine produced a narrow and deep minor groove. 模拟结果表明DNA与可逆脒小分子的结合会产生一个又窄又深的小沟。